PUBLICATIONS

PUBLICATIONS-2026

1. 1. 74. Jin, F.* (2026) Steering complex rhythms. Nat. Comput. Sci. DOI: 10.1038/s43588-026-01064-z.
      73. Ni, L.#, Huang, Y.#*, Huang, Y., Yu, Y., Xiong, J., Wen, H., Xiao, W., Li, B., Huang, S., Liang, H.*, and Jin, F.* (2026) Mechanical compression activates cAMP signaling in Pseudomonas aeruginosa. Cell Rep. 45, 118114. DOI: 10.1016/j.celrep.2026.118114.
      72. Yang, S., and Jin, F.* (2026) Why the temporal dimension matters in cellular signalling. Nat. Cell Biol. 28, 1599–1605. DOI: 10.1038/s41556-026-02006-7.

PUBLICATIONS-2025

1. 1. 71. Zhang, R.#, Wan, S.#, Xiong, J., Ni, L., Li, Y., Huang, Y., Li, B., Li, M., Yang, S.*, and Jin, F.* (2025) Decoding frequency-modulated signals increases information entropy in bacterial second messenger networks. Nat. Phys. 21, 1728–1740. DOI: 10.1038/s41567-025-03030-4.
      70. 杨帅, 徐韵东, 金帆* (2025) 合成生物学在医学诊疗中的应用与伦理治理：技术突破与价值边界. 合成生物学. DOI: 10.12211/2096-8280.2025-033.
      69. Xiong, J.#, Wang, L.#, Lin, J.#, Ni, L., Zhang, R., Yang, S., Huang, Y., Chu, J.*, and Jin, F.* (2025) Quantifying second-messenger information transmission in bacteria. Nat. Phys. 21, 1009–1018. DOI: 10.1038/s41567-025-02848-2. Research briefing: Bacterial second messengers achieve extraordinary signal capacity. Nat. Phys. 21, 883–884. DOI: 10.1038/s41567-025-02856-2.
      68. Zhang, J.#, Luo, Y.#, Zong, Y., Lu, S., Shi, Y.*, Jin, F.*, and Zhao, K.* (2025) The role of PilU in the surface behaviors of Pseudomonas aeruginosa. mLife 4, 83–95. DOI: 10.1002/mlf2.12165.

PUBLICATIONS-2023

1. 1. 67. Zhang, R.#, Huang, Y.#, Li, M., Wang, L., Li, B., Xia, A., Li, Y., Yang, S.*, and Jin, F.* (2023) High-throughput, microscopy-based screening and quantification of genetic elements. mLife 2, 450–461. DOI: 10.1002/mlf2.12096.
      66. Gao, Y.#, Wei, J.#, Pu, L., Fu, S., Xing, X., Zhang, R.*, and Jin, F.* (2023) Remotely Controllable Engineered Bacteria for Targeted Therapy of Pseudomonas aeruginosa Infection. ACS Synth. Biol. 12, 1961–1971. DOI: 10.1021/acssynbio.2c00655.
      65. Fu, S.#, Zhang, R.#*, Gao, Y., Xiong, J., Li, Y., Pu, L., Xia, A., and Jin, F.* (2023) Programming the lifestyles of engineered bacteria for cancer therapy. Natl. Sci. Rev. 10, nwad031. DOI: 10.1093/nsr/nwad031.
      64. Cao, Z.#, Zuo, W.#, Wang, L., Chen, J., Qu, Z., Jin, F., and Dai, L.* (2023) Spatial profiling of microbial communities by sequential FISH with error-robust encoding. Nat. Commun. 14, 1477. DOI: 10.1038/s41467-023-37188-3.
      63. 付生伟, 金帆* (2023) 若干裂解基因盒子的表征及应用. 生物工程学报, 39(3): 1142–1162. DOI: 10.13345/j.cjb.220757.

PUBLICATIONS-2022

1. 1. 62. Li, F., Liu, X.-Y., Ni, L.*, and Jin, F.* (2023) AIDmut-Seq: a Three-Step Method for Detecting Protein-DNA Binding Specificity. Microbiol. Spectr. 11, e03783-22. DOI: 10.1128/spectrum.03783-22.
      60. Chen, W.#, Zhang, J.#, Li, F.#, Wang, C., Zhang, Y., Xia, A., Ni, L.*, and Jin, F.* (2022) Genome-Wide Analysis of Gene Expression Noise Brought About by Transcriptional Regulation in Pseudomonas aeruginosa. mSystems 7, e00963-22. DOI: 10.1128/msystems.00963-22.
      59. Xia, A.#, Zhang, R.#, Huang, Y., Ni, L., Pu, L., Li, Y., Yang, S.*, and Jin, F.* (2022) An adaptive tracking illumination system for optogenetic control of single bacterial cells. Appl. Microbiol. Biotechnol. 106, 6775–6784. DOI: 10.1007/s00253-022-12177-6.
      58. Wei, J., and Jin, F.* (2022) Illuminating bacterial behaviors with optogenetics. Curr. Opin. Solid State Mater. Sci. 26, 101023. DOI: 10.1016/j.cossms.2022.101023.
      57. 李飞旋, 倪磊, 金帆* (2023) 铜绿假单胞菌中快速基因操作工具的开发和应用. 生物工程学报, 39(4): 1789–1803. DOI: 10.13345/j.cjb.220579.
      56. 陈文辉, 金帆* (2023) 铜绿假单胞菌中S型绿脓杆菌素与荧光嗜铁素的功能协同性分析. 生物工程学报, 39(4): 1562–1577. DOI: 10.13345/j.cjb.220608.
      55. 张亭, 冷梦甜, 金帆, 袁海* (2022) 合成生物研究重大科技基础设施概述. 合成生物学, 3(1): 184–194. DOI: 10.12211/2096-8280.2021-077.

PUBLICATIONS-2021

1. 1. 54. Cheng, X.#, Pu, L.#, Fu, S.#, Xia, A., Huang, S., Ni, L., Xing, X., Yang, S.*, and Jin, F.* (2021) Engineering Gac/Rsm Signaling Cascade for Optogenetic Induction of the Pathogenicity Switch in Pseudomonas aeruginosa. ACS Synth. Biol. 10, 1520–1530. DOI: 10.1021/acssynbio.1c00075.
      53. Xia, A., Qian, M., Wang, C., Huang, Y., Liu, Z.*, Ni, L.*, and Jin, F.* (2021) Optogenetic Modification of Pseudomonas aeruginosa Enables Controllable Twitching Motility and Host Infection. ACS Synth. Biol. 10, 531–541. DOI: 10.1021/acssynbio.0c00559.
      52. Wong, G. C. L.* et al. (Yang, S.; Jin, F.) (2021) Roadmap on emerging concepts in the physical biology of bacterial biofilms: from surface sensing to community formation. Phys. Biol. 18, 051501. DOI: 10.1088/1478-3975/abdc0e.
      51. 杨帅, 金帆* (2021) 单细菌表型的高通量表征和控制. 科学通报, 66(3): 367–383. DOI: 10.1360/TB-2020-0486.
      50. 金帆*#, 李奉庭#, 夏霖* (2021) CRISPR/Cas在定向进化技术中的应用. 集成技术, 10(4): 33–49.
      49. 金帆*#, 高艳梅#, 黄亚佳, 蒲璐, 夏霖* (2021) 铜绿假单胞菌感染治疗现状. 集成技术, 10(4): 50–66.
      48. 辛颖#, 徐宝琪#, 王军杰#, 张荣荣#, 温慧, 王金娟, 梁帆, 金帆, 梁卓, 黄建东*, 黄术强* (2021) 用于高分辨率成像的肺器官芯片构建及肺炎模型应用研究. 集成技术, 10(4): 126–136.

PUBLICATIONS-2020

1. 1. 47. Yang, S., and Jin, F.* (2021) Characterization and control of bacterial phenotypes at the single cell level. Chin. Sci. Bull. 66, 367–383. DOI: 10.1360/TB-2020-0486.
      46. 蒲璐, 黄亚佳, 杨帅, 金帆* (2020) 合成生物学在感染性疾病防治中的应用. 合成生物学, 1(2): 141–157. DOI: 10.12211/2096-8280.2020-021.
      45. Huang, Y., Yang, S., Chen, W., Li, F., Xia, A., Ni, L.*, Yang, G.*, and Jin, F.* (2020) A Synthetic Genetic Circuit Enables Precise Quantification of Direct Repeat Deletion in Bacteria. ACS Synth. Biol. 9, 1041–1050. DOI: 10.1021/acssynbio.9b00256.
      44. Cheng, Z.-H.#, Xiong, J.-R.#, Min, D., Cheng, L., Liu, D.-F.*, Li, W.-W., Jin, F., Yang, M., and Yu, H.-Q. (2020) Promoting bidirectional extracellular electron transfer of Shewanella oneidensis MR-1 for hexavalent chromium reduction via elevating intracellular cAMP level. Biotechnol. Bioeng. 117, 1294–1303. DOI: 10.1002/bit.27305.

PUBLICATIONS-2019

1. 1. 43. Wang, C.#, Chen, W.#, Xia, A., Zhang, R., Huang, Y., Yang, S., Ni, L.*, and Jin, F.* (2019) Carbon starvation induces the expression of PprB-regulated genes in Pseudomonas aeruginosa. Appl. Environ. Microbiol. 85, e01705-19. DOI: 10.1128/AEM.01705-19.
      42. Han, J.#, Xia, A.#, Huang, Y., Ni, L., Chen, W., Jin, Z., Yang, S.*, and Jin, F.* (2019) Simultaneous Visualization of Multiple Gene Expression in Single Cells Using an Engineered Multicolor Reporter Toolbox and Approach of Spectral Crosstalk Correction. ACS Synth. Biol. 8, 2536–2546. DOI: 10.1021/acssynbio.9b00223.
      41. Armbruster, C. R.#, Lee, C. K.#, Parker-Gilham, J., de Anda, J., Xia, A., Zhao, K., Murakami, K., Tseng, B. S., Hoffman, L. R., Jin, F.*, Harwood, C. S., Wong, G. C. L.*, and Parsek, M. R.* (2019) Heterogeneity in surface sensing suggests a division of labor in Pseudomonas aeruginosa populations. eLife 8, e45084. DOI: 10.7554/eLife.45084.
      40. Xia, A.#, Yang, S.#, Zhang, R., Ni, L., Xing, X.*, and Jin, F.* (2019) Imaging the Separation Distance between the Attached Bacterial Cells and the Surface with a Total Internal Reflection Dark-Field Microscope. Langmuir 35, 8860–8866. DOI: 10.1021/acs.langmuir.9b01378.
      39. Lee, E. Y.#, Zhang, C.#, Di Domizio, J., Jin, F., Connell, W., Hung, M., Malkoff, N., Veksler, V., Gilliet, M., Ren, P.*, and Wong, G. C. L.* (2019) Helical antimicrobial peptides assemble into protofibril scaffolds that present ordered dsDNA to TLR9. Nat. Commun. 10, 1012. DOI: 10.1038/s41467-019-08868-w.
      38. 黄亚佳, 倪磊, 金帆, 杨光* (2019) 基于高通量显微成像及分析技术的DNA重排研究. 集成技术, 8(6): 31–38.

PUBLICATIONS-2018

1. 1. 37. Xia, A.#, Han, J.#, Jin, Z., Ni, L., Yang, S.*, and Jin, F.* (2018) Dual-Color Fluorescent Timer Enables Detection of Growth-Arrested Pathogenic Bacterium. ACS Infect. Dis. 4, 1666–1670. DOI: 10.1021/acsinfecdis.8b00129.
      36. Yang, S.#, Cheng, X.#, Jin, Z., Xia, A., Ni, L., Zhang, R., and Jin, F.* (2018) Differential Production of Psl in Planktonic Cells Leads to Two Distinctive Attachment Phenotypes in Pseudomonas aeruginosa. Appl. Environ. Microbiol. 84, e00700-18. DOI: 10.1128/AEM.00700-18.
      35. Huang, Y.#, Xia, A.#, Yang, G.*, and Jin, F.* (2018) Bioprinting Living Biofilms through Optogenetic Manipulation. ACS Synth. Biol. 7, 1195–1200. DOI: 10.1021/acssynbio.8b00003.
      34. Jin, Z.#, Li, J.#, Ni, L., Zhang, R., Xia, A., and Jin, F.* (2018) Conditional privatization of a public siderophore enables Pseudomonas aeruginosa to resist cheater invasion. Nat. Commun. 9, 1383. DOI: 10.1038/s41467-018-03791-y.
      33. 金帆 (2018) 从“设计生命”到理解生命：对生命科学的哲学阐释. 文化纵横, 1: 122–131.

PUBLICATIONS-2017

1. 1. 32. Pu, L.#, Yang, S.#, Xia, A., and Jin, F.* (2018) Optogenetics Manipulation Enables Prevention of Biofilm Formation of Engineered Pseudomonas aeruginosa on Surfaces. ACS Synth. Biol. 7, 200–208. DOI: 10.1021/acssynbio.7b00273.
      31. 倪磊*, 金震宇, 杨帅, 金帆 (2017) 铜绿假单胞菌蹭行运动单细胞分析方法的建立及应用. 生物工程学报, 33(9): 1611–1624. DOI: 10.13345/j.cjb.170131.
      30. Zhang, R.#, Xia, A.#, Ni, L., Li, F., Jin, Z., Yang, S., and Jin, F.* (2017) Strong Shear Flow Persister Bacteria Resist Mechanical Washings on the Surfaces of Various Polymer Materials. Adv. Biosyst. 1, 1700161. DOI: 10.1002/adbi.201700161.
      29. Brill-Karniely, Y.*, Jin, F., Wong, G. C. L.*, Frenkel, D., and Dobnikar, J.* (2017) Emergence of complex behavior in pili-based motility in early stages of P. aeruginosa surface adaptation. Sci. Rep. 7, 45467. DOI: 10.1038/srep45467.

PUBLICATIONS-2016

1. 1. 28. Ni, L.#, Yang, S.#, Zhang, R., Jin, Z., Chen, H., Conrad, J. C.*, and Jin, F.* (2016) Bacteria differently deploy type-IV pili on surfaces to adapt to nutrient availability. npj Biofilms Microbiomes 2, 15029. DOI: 10.1038/npjbiofilms.2015.29.
      27. Cai, J.*, Yue, Y., Wang, Y., Jin, Z., Jin, F., and Wu, C.* (2016) Quantitative study of effects of free cationic chains on gene transfection in different intracellular stages. J. Control. Release 238, 71–79. DOI: 10.1016/j.jconrel.2016.07.031.
      26. Lee, E. Y., Lee, C. K., Schmidt, N. W., Jin, F., Lande, R., Curk, T., Frenkel, D., Dobnikar, J., Gilliet, M., and Wong, G. C. L.* (2016) A review of immune amplification via ligand clustering by self-assembled liquid-crystalline DNA complexes. Adv. Colloid Interface Sci. 232, 17–24. DOI: 10.1016/j.cis.2016.02.003.
      25. Gao, P.#, Yi, Z.#, Xing, X., Ngai, T.*, and Jin, F.* (2016) Influence of an Additive-Free Particle Spreading Method on Interactions between Charged Colloidal Particles at an Oil/Water Interface. Langmuir 32, 4909–4916. DOI: 10.1021/acs.langmuir.6b01362.

PUBLICATIONS (24-1) – 2015~